Perspectives on diacylglycerol-induced improvement of insulin sensitivity in type 2 diabetes

Diacylglycerol (DAG)-based edible oils have attracted increasing research interest owing to their health-promoting properties. Recent animal and human studies showed that an increased 1,2-DAG content in the liver skeletal muscle may cause insulin resistance. However, earlier using models or humans reported dietary DAGs with a 1,2-DAGs 1,3-DAGs ratio of approximately 3:7 could improve sensitivity type 2 diabetic patients. This conflict raises question whether there is link between ingested endogenous during metabolism. To make contribution this field, review provides overview metabolic pathways biological roles (ingested endogenous) change sensitivity. Accordingly, strategies for further investigations on metabolism are proposed.